Circular RNA Biomarker Based Approach to Depression Diagnosis
May 15, 2025
Today's featured article: “Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors”
by Minzi Ju, Zhongkun Zhang, Feng Gao, Gang Chen, Sibo Zhao, Dan Wang, Huijuan Wang , Yanpeng Jia, Ling Shen, Yonggui Yuan, Honghong Yao
These results indicate that the level of circATF7IP positively correlates with MDD pathogenesis, and SALNP delivery of si-circATF7IP via intranasal administration is an effective strategy to ameliorate LPS-induced depressive-like behaviors.
Keywords: CircRNA; depression; lipid nanoparticle; neuroinflammation; oligonucleotide.
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